So I plotted all the 255 colors on a grid based on Lab coloration. I made layers to group together colors with similar L values. It helps to illustrate some of the space you have to traverse.Luminous yellow is out there, so it makes sense that it’s harder to mutate. I bet it’s impossible to mix. The best you could manage would be to mix it with some of the colors close to it and double up on the yellow. As long as you don’t crowd out the yellow. Same with all the extreme pointy ends.