I’m pretty sure you can make it man. I never went over 150 or so but at least one of my larger layouts could have been probably inverted and duplicated upside down.
For me though, it was more about getting more generators per machine 
I guess if you started spiraling machines along spark link runs you could get a heck of a lot of machines on there, and still have them all be somewhat usable.
Ehhh, editing in to say: that thread reminded me my big workshop was 180 not 150. I don’t think I could have flipped/doubled that layout and still included all eight generator sets.
As @Xaldafax is discussing, getting more generators shared out is a very particular process.