Experimentation and recording your results is basically is the best option I’m afraid. The maths/science/algorithms used I can follow well enough to use them but unfortunately I am not smart enough to be able to explain it I am sorry.
Maybe some of these links will help you though.
A few friends and I were recording our results in this spreadsheet… however there was a bug in the mutation system that was patched recently so a lot of these results are now incorrect I’m afraid…but ill share anyway as this may also give you some direction.